Tirzepatide

Overview

Torsena is a European supplier of research-grade Tirzepatide dedicated to qualified laboratories and research institutions. Orders ship from EU-based stock with batch documentation available upon request. Single vials and bulk quantities are available for ongoing study protocols.

Lot & Supply Format

• Purity ≥99% verified by HPLC/MS analysis
• Mannitol-free formulation (no bulking agents or buffers)
• Lyophilized peptide in sealed glass research vials
• Single vials and bulk quantities available
• CoA transparency: batch-specific certificate of analysis available upon request
• Shipped from Europe with temperature-appropriate packaging

What is Tirzepatide?

Tirzepatide is a synthetic 39-amino acid peptide investigated in metabolic research as a dual receptor agonist. It exhibits simultaneous binding activity at two incretin receptor targets:

GLP-1 Receptor — studied in incretin pathway signaling, glucose-dependent insulinotropic research, and satiety signaling models.

GIP Receptor — investigated in complementary incretin signaling, lipid metabolism modulation, and nutrient-dependent metabolic pathway research.

Tirzepatide incorporates a C20 fatty diacid modification (eicosanedioic acid) at Lys20 via a γGlu-miniPEG linker. This modification facilitates albumin binding and extends the compound’s pharmacokinetic profile in experimental models. Tirzepatide also features an Aib substitution at position 2 for enhanced enzymatic stability.

The dual incretin approach distinguishes Tirzepatide from single-agonist GLP-1 compounds such as semaglutide. Published literature characterizes the dual mechanism as producing synergistic metabolic signaling effects in controlled research models.

Supplied exclusively for in-vitro and ex-vivo research by qualified laboratories. Not intended for human or animal administration.

Mechanistic Overview

GLP-1 Axis
Tirzepatide activates the GLP-1 receptor with potency characterized in binding affinity studies as comparable to native GLP-1. GLP-1 receptor activation in experimental models has been associated with glucose-dependent insulin secretion, modulation of gastric motility signaling, and central appetite pathway regulation.

GIP Axis
The glucose-dependent insulinotropic polypeptide receptor component distinguishes Tirzepatide from single-agonist GLP-1 research tools. GIP receptor activation has been examined in models investigating nutrient-dependent insulin secretion potentiation, adipose tissue signaling, and bone metabolism pathways. In dual-agonist experimental models, GIP and GLP-1 co-activation has been observed to produce additive signaling effects on metabolic parameters.

Dual Incretin Synergy
Published research characterizes the dual incretin mechanism as producing metabolic signaling responses that exceed those observed with either receptor agonist alone. This synergistic profile has made Tirzepatide a widely referenced research tool for investigating multi-receptor incretin pathway interactions.

Tirzepatide vs Semaglutide vs Retatrutide

Characteristic	Tirzepatide	Semaglutide	Retatrutide
Receptor Targets	Dual: GLP-1, GIP	Single: GLP-1	Triple: GLP-1, GIP, Glucagon
Research Focus	Dual incretin pathway research	GLP-1 signaling models	Multi-receptor metabolic signaling
Molecular Length	39 amino acids	31 amino acids	39 amino acids
Acylation	C20 fatty diacid	C18 fatty diacid	C18 fatty diacid
Key Distinction	Dual incretin synergy	Most characterized GLP-1 tool	Glucagon axis activity
CAS Number	2023788-19-2	910463-68-2	2381089-83-2

For triple-agonist research, see also our Retatrutide research peptide.

Reconstitution & Storage

Lyophilized Tirzepatide is stable at -20°C for long-term storage. Reconstitution for in-vitro work is typically performed using bacteriostatic water or sterile saline. Reconstituted aliquots are generally stored at 2-8°C for short-term use. For extended storage, aliquot and freeze at -20°C to preserve peptide integrity. Acylated peptides like Tirzepatide can be sensitive to surfactant interactions and prolonged exposure to plastic surfaces — use low-binding tubes and avoid prolonged storage in standard polypropylene where possible. Researchers should follow institutional SOPs for handling lyophilized acylated peptides.

Why Torsena

• Analytical Testing — Purity verified by third-party HPLC and mass spectrometry
• No Fillers — Mannitol-free, no bulking agents or buffer salts
• Batch Transparency — Certificate of Analysis available upon request
• Consistent Availability — Single vials and bulk quantities maintained in stock
• EU Distribution — Shipped from European fulfillment with tracked courier
• Full Documentation — Batch-specific CoA and MSDS available for institutional procurement

Product Specifications

Chemical Name: Tirzepatide
Synonyms: LY3299176
CAS Number: 2023788-19-2
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: 4813.45 g/mol
Purity: ≥99% (HPLC/MS)
Physical Form: White to off-white lyophilized powder
Additives: None (mannitol-free)
Intended Use: In-vitro / ex-vivo laboratory research only

Amino Acid Sequence

Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Ala-Leu-Asp-Lys*-Ile-Ala-Gln-Lys-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser

Modifications:
*Lys20 acylated with C20 fatty diacid (eicosanedioic acid) via γGlu-miniPEG linker
Aib = α-aminoisobutyric acid at position 2
Peptide Length: 39 amino acids
Type: Linear, acylated

Analytical Transparency

All Torsena research materials are tested for purity and identity by HPLC and mass spectrometry analysis. Batch-specific Certificates of Analysis are available upon request for institutional procurement.

• Reverse-phase HPLC purity determination
• Mass spectrometry identity confirmation
• Appearance and solubility verification
• Endotoxin screening (where applicable)

Related Research Compounds

Researchers studying incretin signaling, metabolic pathways, and multi-receptor pharmacology may also be interested in:

• Retatrutide — triple GLP-1 / GIP / glucagon receptor agonist for metabolic research
• CJC-1295 + Ipamorelin Blend — growth hormone axis research blend
• Ipamorelin — standalone GHS-R1a agonist for somatotroph signaling research