Semax

Overview

Torsena is a European supplier of research-grade Semax dedicated to qualified laboratories and research institutions. Orders ship from EU-based stock with batch documentation available upon request.

Lot & Supply Format

• Purity ≥99% verified by HPLC/MS analysis
• Mannitol-free formulation (no bulking agents or buffers)
• Lyophilized peptide in sealed glass research vials
• Single vials and bulk quantities available
• CoA transparency: batch-specific certificate of analysis available upon request
• Shipped from Europe with temperature-appropriate packaging

What is Semax?

Semax is a synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-7). It carries a C-terminal Pro-Gly-Pro extension. Semax was originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It was designed as a tool for investigating neuropeptide signaling pathways.

The ACTH(4-7) fragment (Met-Glu-His-Phe) is a sequence identified in early neuropeptide research. It retains neurotropic activity without the adrenocorticotropic effects of full-length ACTH. The Pro-Gly-Pro C-terminal extension was engineered to enhance metabolic stability against peptidase degradation. This extends the compound’s functional duration in experimental systems.

Semax is one of the most widely referenced synthetic neuropeptides in neurotrophin signaling and neuroprotection research. It has a substantial body of published literature from Russian and international research groups.

Supplied exclusively for in-vitro and ex-vivo research by qualified laboratories. Not intended for human or animal administration.

Mechanistic Overview

Neurotrophin Pathway Research
Published research has examined Semax in models of neurotrophin signaling. The primary pathways studied are BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression. In vitro studies have characterized effects on neurotrophin mRNA expression levels and downstream TrkB receptor signaling in neuronal culture models.

Melanocortin System Interaction
As a derivative of the ACTH(4-7) sequence, Semax has been investigated for interactions with melanocortin receptor subtypes in CNS tissue models. Research has examined its binding profile across MC3R and MC4R. Studies have also characterized the relationship between melanocortin receptor activation and neuroplasticity-associated signaling cascades.

Neuroprotection Models
Semax has been studied in experimental oxidative stress, excitotoxicity, and ischemia-reperfusion models. Published findings describe effects on inflammatory cytokine expression profiles. Research has also characterized antioxidant enzyme pathway modulation under controlled experimental conditions.

Semax vs Selank

Characteristic	Semax	Selank
Parent Sequence	ACTH(4-7)	Tuftsin (Thr-Lys-Pro-Arg)
C-Terminal Extension	Pro-Gly-Pro	Pro-Gly-Pro
Length	7 amino acids	7 amino acids
Research Focus	Neurotrophin signaling, neuroprotection	Immune-neuro signaling, anxiolytic models
Pathway Targets	BDNF/NGF, melanocortin	IL-6, enkephalin metabolism
CAS Number	80714-61-0	129954-34-3

For paired immunopeptide research, see also our Selank research peptide.

Reconstitution & Storage

Lyophilized Semax is stable at -20°C for long-term storage. Reconstitution for in-vitro work is typically performed using bacteriostatic water or sterile saline. Reconstituted aliquots are generally stored at 2-8°C for short-term use. For extended storage, aliquot and freeze at -20°C to preserve peptide integrity. Researchers should follow institutional SOPs for handling lyophilized peptides.

Why Torsena

• Analytical Testing — Purity verified by third-party HPLC and mass spectrometry
• No Fillers — Mannitol-free, no bulking agents or buffer salts
• Batch Transparency — Certificate of Analysis available upon request
• Consistent Availability — Single vials and bulk quantities maintained in stock
• EU Distribution — Shipped from European fulfillment with tracked courier
• Full Documentation — Batch-specific CoA and MSDS available for institutional procurement

Product Specifications

Chemical Name: Semax
Synonyms: ACTH(4-7) Pro-Gly-Pro analog, Semax heptapeptide
CAS Number: 80714-61-0
Molecular Formula: C₃₇H₅₁N₉O₁₀
Molecular Weight: 813.86 g/mol
Purity: ≥99% (HPLC/MS)
Physical Form: White lyophilized powder
Additives: None (mannitol-free)
Intended Use: In-vitro / ex-vivo laboratory research only

Amino Acid Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

Parent Sequence: ACTH(4-7) = Met-Glu-His-Phe
Stabilizing Extension: Pro-Gly-Pro (C-terminal)
Peptide Length: 7 amino acids
Type: Linear

Analytical Transparency

All Torsena research materials are tested for purity and identity by HPLC and mass spectrometry analysis. Batch-specific Certificates of Analysis are available upon request for institutional procurement.

• Reverse-phase HPLC purity determination
• Mass spectrometry identity confirmation
• Appearance and solubility verification
• Endotoxin screening (where applicable)

Related Research Compounds

Researchers studying neuropeptide signaling and CNS function may also be interested in:

• Selank — tuftsin-derived heptapeptide for immune-neuro signaling research